Most Potent Mushrooms
BY IGONK, FEBRUARY 16, 2026
Webin the case of psilocybin mushrooms, the amount of psilocybin and psilocin, the active psychedelic compounds, are the primary determinants of potency. Strains with higher psilocybin concentrations tend to be the most potent. Webthe most potent species of magic mushroom is psilocybe azurescens, which produces an average psilocybin level of 1.
10% and peak levels reaching 1. 80%.